Medical Supramolecular Chemistry of Polyamines – Pharmacological Applications

Prof. Enrique García España

Title: Medical Supramolecular Chemistry of Polyamines. Pharmacological Applications.
When: 11:30 CET, Wednesday, March 23rd, 2022.
Place: Sala de Grados, Module 8, Faculty of Sciences, Universidad Autónoma de Madrid.
Speaker: Prof. Enrique García España from the Institute of Molecular Science, University of Valencia.

Supramolecular chemistry, defined as “chemistry beyond molecules”, is based on the construction of chemical systems made up of molecular components that associate through non-covalent interactions. A logical branch of supramolecular chemistry extends into medicinal chemistry.
In this talk, a supramolecular approach is discussed, including concepts of coordination chemistry, aimed at the design of systems with antioxidant, antitumor and/or antiparasitic activity based on polyamine compounds. The choice of polyamines as base structures is not surprising, considering their ubiquitous presence in biological systems and the variety of biochemical functions they exert. Within this supramolecular approach to drug development, the incorporation of active molecules on the surface of particles will be discussed, in order to take advantage of the multivalence effect, seeking to increase activity, direct drugs to specific targets and explore new mechanisms of action.

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